DIABLO antibody , Cat. # FNab02384

SKU: FNab02384

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO.

Immunogen:diablo homolog(Drosophila)

Synonyms:DIABLO, Diablo homolog, mitochondrial, DIABLO S, SMAC, SMAC3

Observed MW:20 kDa

Uniprot ID:Q9NR28

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200

Gene ID:56616

Research Area:Cancer