DFFA Polyclonal Antibody

SKU: E-AB-10383

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: DFFA

Target Synonym: A330085O09Rik;Caspase activated deoxyribonuclease inhibitor short form;DFF 1;DFF 45;DFF alpha;DFF-45;DFF1;DFF35;DFF45;DFFA;Dffa DNA fragmentation factor;alpha subunit;DFFA;DNA fragmentation factor 45 kDa subunit;DNA Fragmentation Factor Alpha Subunit;DNA fragmentation factor subunit alpha;DNA fragmentation factor;45 kD;alpha subunit;DNA fragmentation factor;45kDa;alpha polypeptide (DFFA);transcript variant 1;DNA fragmentation factor;45kDa;alpha polypeptide;DNA fragmentation factor;alpha subunit;DNAation factor 45 kDa subunit;H13;ICAD;ICAD L;ICAD S;Inhibitor of CAD;Inhibitor of Caspase Activated DNase;MGC143066;OTTHUMP00000001903;OTTHUMP00000001904;RP23 121D17.3

Research Areas: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Metabolism

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: O00273

Accession:

Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Concentration: 0.7 mg/mL

Immunogen: Recombinant protein of human DFFA

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:30-1:150

Calculated MW:

ObservedMW: