DCUN1D1 antibody , Cat. # FNab02278

SKU: FNab02278

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8(UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates(PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression(By similarity).

Immunogen:DCN1, defective in cullin neddylation 1, domain containing 1(S. cerevisiae)

Synonyms:DCUN1L1, RP42, SCCRO

Observed MW:28 kDa

Uniprot ID:Q96GG9

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, WB

Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200

Gene ID:54165

Research Area:Metabolism