DCC Polyclonal Antibody

SKU: E-AB-15932

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: DCC

Target Synonym: Colorectal cancer related chromosome sequence 18;Colorectal cancer suppressor;CRC 18;CRC18;CRCR 1;CRCR1;DCC;DCC;Deleted in colorectal cancer protein;Deleted in colorectal carcinoma;Immunoglobulin superfamily DCC subclass member 1;Netrin receptor DCC;Tumor suppressor protein DCC

Research Areas: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Neuroscience

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P43146

Accession:

Background: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Concentration: 0.7 mg/mL

Immunogen: Synthetic peptide of human DCC

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: