DAB2 Rabbit Polyclonal Antibody

SKU: BT-AP08887

Size:100μL

Background:This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells| but is down-regulated or absent from ovarian carcinoma cell lines| suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2| an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras)| via its C-terminal proline-rich sequences| and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research_area:Epigenetics and nuclear signaling; Signal transduction

Target_protein:DAB2

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:DAB2

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P98082; Mouse: P98078; Rat: O88797

Synonyms:DAB2; Disabled homolog 2; DOC-2; Differentially-expressed protein 2)

GeneID:Human: 1601; Mouse: 13132; Rat: 79128