Cytokeratin 8 Monoclonal Antibody

SKU: AN200190P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:KRT8

Target Synonym:CYK;KRT;CYK8;KRT8;CARD2;CARD2;CK 8;CK-8;CK8;CYK8;CYKER;Cytokeratin endo A;Cytokeratin-8;DreK8;EndoA;K2C8;K2C8;K8;Keratin 8;Keratin type II cytoskeletal 8;Keratin;type II cytoskeletal 8;Keratin-8;KO;Krt 2.8;KRT8;MGC118110;MGC174782;MGC53564;MGC85764;sb:cb186;Type-II keratin Kb8;CK 8;CK8;CK-8;CYKER;Cytokeratin endo A;Cytokeratin-8;DreK8;EndoA;K2C8;Keratin;Keratin 8;Keratin type II cytoskeletal 8;Keratin-8;Krt 2.8;MGC118110;MGC174782;MGC53564;MGC85764;sb:cb186;type II cytoskeletal 8;Type-II keratin Kb8

Research Areas:Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:IHC-P;ICC/IF

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:10F13

UNIProt ID:P05787

Accession:

Background:KRT8 (Keratin 8) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. KRT8 is the major component of the intermediate filament cytoskeleton and is predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis.KRT8 overexpression in renal cancer cell lines promoted cell migration and invasion. In contrast, KRT8 knockdown suppressed ccRCC metastasis both in vitro and in vivo.KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis.

Concentration:1 mg/mL

Immunogen:A synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 8

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:IHC-P 1:500-1:5000;ICC/IF 1:20-1:100

Calculated MW:

ObservedMW: