CSPG4 Antibody - Cat. #: CSB-PA006076ESR1HU

SKU: CSB-PA006076ESR1HU

Size :50ul

Clone Number:

Aliases:4732461B14Rik antibody; AN2 antibody; AN2 proteoglycan antibody; Chondroitin sulfate proteoglycan 4 (melanoma-associated) antibody; Chondroitin sulfate proteoglycan 4 antibody; Chondroitin sulfate proteoglycan NG2 antibody; Cspg4 antibody; Cspg4 chondroitin sulfate proteoglycan 4 antibody; CSPG4_HUMAN antibody; HMW-MAA antibody; HSN tumor-specific antigen antibody; Kiaa4232 antibody; MCSP antibody; MCSPG antibody; MEL-CSPG antibody; Melanoma chondroitin sulfate proteoglycan antibody; Melanoma-associated chondroitin sulfate proteoglycan antibody; MELCSPG antibody; MSK16 antibody; NG2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q6UVK1

Immunogen:Recombinant Human Chondroitin sulfate proteoglycan 4 protein (1950-2210AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CSPG4

Research Areas:Neuroscience; Cancer; Tags & Cell Markers