CPSF4 Polyclonal Antibody

SKU: E-AB-14891

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: CPSF4

Target Synonym: cleavage and polyadenylation specific factor 4;30kDa;Cleavage and polyadenylation specificity factor 30 kDa subunit;Cleavage and polyadenylation specificity factor subunit 4;cleavage polyadenylation specificity factor;30kD;CPSF 30 kDa subunit;CPSF30;Cpsf4;CPSF4;NAR;Neb-1;NEB1;No arches homolog;no arches like zinc finger protein;NS1 effector domain binding protein 1;NS1 effector domain-binding protein 1;OTTHUMP00000206235;OTTHUMP00000206237;OTTHUMP00000206239

Research Areas: Epigenetics and Nuclear Signaling;Microbiology

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: O95639

Accession:

Background: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Concentration: 0.4 mg/mL

Immunogen: Recombinant protein of human CPSF4

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 30kDa

ObservedMW: