CLK1 Antibody - Cat. #: CSB-PA556042

SKU: CSB-PA556042

Size :100ul

Clone Number:

Aliases:CDC like kinase 1 antibody; CDC-like kinase 1 antibody; CDC28/CDC2 like kinase antibody; CLK antibody; CLK/STY antibody; Clk1 antibody; CLK1_HUMAN antibody; Dual specificity protein kinase CLK1 antibody; Protein tyrosine kinase STY antibody; STY antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49759

Immunogen:Synthesized peptide derived from internal of Human CLK1.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500

Background:Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.

Johnson K.W., J. Biol. Chem. 266:3402-3407(1991).
Hanes J.J., J. Mol. Biol. 244:665-672(1994).
Olsen J.V., Cell 127:635-648(2006).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CLK1

Research Areas:Epigenetics and Nuclear Signaling;Signal transduction