Cleaved-Thrombin APII (R327) rabbit pAb

SKU: ES1055

Size: 100μL

Source:Rabbit

Applications:WB;ELISA

Reactivity:Human;Rat;Mouse;

Dilution:Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human THRB. AA range:278-327

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):19kD

Human_gene_id:2147

Human_swiss_prot_no:P00734

Subcellular_location:Secreted, extracellular space.

Other_name:F2; Prothrombin; Coagulation factor II

Background:Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],