Cleaved-CASP4 p20 (Q81) Polyclonal Antibody

SKU: E-AB-30021

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: Cleaved-Caspase-4 p20 (Q81)

Target Synonym: Apoptotic cysteine protease Mih1/TX;CASP-4;CASP4;CASP4;Caspase 4 apoptosis related cysteine peptidase;Caspase-4 subunit 2;Caspase4;ICE(rel)-II;ICE(rel)II;ICEREL II;ICH2;Mih1/TX;Protease ICH-2;Protease TX;TX

Research Areas: Cancer;Cell Biology;Metabolism

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: WB;IHC-p

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P49662

Accession:

Background: This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

Concentration: 1mg/mL

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-4 p20

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:100-1:300

Calculated MW: 43kDa

ObservedMW: 43+22kDa