CLASP2 Antibody, HRP conjugated - Cat. #: CSB-PA005472LB01HU

SKU: CSB-PA005472LB01HU

Size :50ug

Clone Number:

Aliases:CLAP2_HUMAN antibody; CLASP 2 antibody; Clasp2 antibody; CLIP associating protein 2 antibody; CLIP-associating protein 2 antibody; Cytoplasmic linker associated protein 2 antibody; Cytoplasmic linker-associated protein 2 antibody; hOrbit2 antibody; KIAA0627 antibody; Multiple asters (Mast) like homolog 2 antibody; Protein Orbit homolog 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75122

Immunogen:Recombinant Human CLIP-associating protein 2 protein (226-381AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CLASP2

Research Areas:Cell biology; Signal transduction