CHEK2 Polyclonal Antibody

SKU: E-AB-53245

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:CHEK2

Target Synonym:CDS 1;Cds1;Cds1 homolog;Checkpoint kinase 2;Checkpoint like protein CHK2;CHEK 2;Chek2;Chk 2;CHK2 checkpoint homolog (S. pombe);CHK2 checkpoint homolog;CHK2;hCds1;HuCds 1;LFS 2;LFS2;PP1425;RAD 53;RAD53;Rad53 homolog;Serine/threonine protein kinase Chk2;Serine/threonine-protein kinase Chk2

Research Areas:Cancer;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O96017

Accession:

Background:In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Concentration:0.66 mg/mL

Immunogen:Synthetic peptide of human CHEK2

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:WB 1:500-1:2000

Calculated MW:61 kDa

ObservedMW:Refer to figures