CHD8 rabbit pAb

SKU: ES9540

Size: 100μL

Source:Rabbit

Applications:IHC;IF

Reactivity:Human;Rat;Mouse;

Dilution:IHC-p 1:50-300

Immunogen:Synthesized peptide derived from part region of human protein

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):283kD

Human_gene_id:57680

Human_swiss_prot_no:Q9HCK8

Subcellular_location:Nucleus . Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. .

Other_name:

Background:This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010],