CHCHD4 Antibody, Biotin conjugated - Cat. #: CSB-PA850802HD01HU

SKU: CSB-PA850802HD01HU

Size :50ug

Clone Number:

Aliases:CHCHD4 antibody; MIA40Mitochondrial intermembrane space import and assembly protein 40 antibody; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8N4Q1

Immunogen:Recombinant Human Mitochondrial intermembrane space import and assembly protein 40 protein (1-142AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CHCHD4

Research Areas:Others