CDKN1B Monoclonal Antibody

SKU: BT-MCA3324

Size:100μL

Background:p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Research_area:Cell Biology

Target_protein:CDKN1B

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:3D8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CDKN1B

Immunogen:Purified recombinant fragment of human CDKN1B expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):22kDa

UniProt accession:P46527

Synonyms:KIP1, MEN4, CDKN4, MEN1B, P27KIP1, CDKN1B

GeneID:1027