CDK5R1 Antibody - Cat. #: CSB-PA932439

SKU: CSB-PA932439

Size :100ul

Clone Number:

Aliases:CD5R1_HUMAN antibody; CDK5 activator 1 antibody; CDK5P35 antibody; CDK5R antibody; CDK5R1 antibody; Cyclin dependent kinase 5 regulatory subunit 1 antibody; Cyclin-dependent kinase 5 activator 1 antibody; Cyclin-dependent kinase 5 regulatory subunit 1 antibody; NCK 5A antibody; Neuronal CDK5 activator antibody; p23 antibody; p25 antibody; p35 antibody; Regulatory partner for CDK5 kinase antibody; Tau protein kinase II 23 kDa subunit antibody; TPKII regulatory subunit antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q15078

Immunogen:Synthesized peptide derived from internal of Human CDK5R1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500

Background:p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Tsai L.-H., Nature 371:419-423(1994).
Patrick G.N., Nature 402:615-622(1999).
Kesavapany S., J. Neurosci. 24:4421-4431(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CDK5R1

Research Areas:Epigenetics and Nuclear Signaling?Neuroscience;Cell biology;Signal transduction