CD45R Monoclonal Antibody

SKU: BT-MCA2348

Size:100μL

Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Research_area:Others

Target_protein:CD45R

applications:WB, IHC, ICC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:2H3E2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD45R

Immunogen:Purified recombinant fragment of human CD45R (AA: extra 378-577) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):147.5kDa

UniProt accession:P08575

Synonyms:PTPRC, LCA, LY5, B220, L-CA, T200, CD45, GP180

GeneID:5788