CD43 Monoclonal Antibody

SKU: BT-MCA4432

Size:100μL

Background:This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome.

Research_area:Others

Target_protein:CD43

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:1H8B10

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD43

Immunogen:Purified recombinant fragment of human CD43 (AA: extra 20-253) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):40.3kDa

UniProt accession:P16150

Synonyms:SPN, LSN, GALGP, GPL115

GeneID:6693