CD360 Monoclonal Antibody

SKU: BT-MCA3145

Size:100μL

Background:The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Research_area:Others

Target_protein:CD360

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:1C3B12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD360

Immunogen:Purified recombinant fragment of human CD360 (AA: extra 20-232) expressed in HEK293-6e cells supernatant.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):59.1kDa

UniProt accession:Q9HBE5

Synonyms:IL21R, NILR, IMD56

GeneID:50615