CD299 rabbit pAb

SKU: ES8703

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Mouse;Rat

Dilution:WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000

Immunogen:Synthetic peptide from human protein at AA range: 271-320

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):60kD

Human_gene_id:10332

Human_swiss_prot_no:Q9H2X3

Subcellular_location:[Isoform 1]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 5]: Secreted .; [Isoform 6]: Secreted .; [Isoform 7]: Secreted .; [Isoform 10]: Secreted .

Other_name:C-type lectin domain family 4 member M (CD209 antigen-like protein 1;DC-SIGN-related protein;DC-SIGNR;Dendritic cell-specific ICAM-3-grabbing non-integrin 2;DC-SIGN2;Liver/lymph node-specific ICAM-3-grabbing non-integrin;L-SIGN;CD antigen CD299)

Background:This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations