CD10 Polyclonal Antibody

SKU: E-AB-12794

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:MME

Target Synonym:Atriopeptidase;CALLA;CD10;CD10 antigen;Common acute lymphocytic leukemia antigen;DKFZp686O16152;EC 3.4.24.11;Enkephalinase;EPN;Membrane metallo endopeptidase (neutral endopeptidase;enkephalinase);Membrane metallo endopeptidase (neutral endopeptidase;enkephalinase;CALLA;CD10);Membrane metallo endopeptidase;Membrane metallo endopeptidase variant 1;Membrane metallo endopeptidase variant 2;Membrane metalloendopeptidase;Membrane metalloendopeptidase neutral endopeptidase enkephalinase;Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10;Membrane metalloendopeptidase variant 1;Membrane metalloendopeptidase variant 2;MGC126681;MGC126707;MME;NEP;NEP;Neprilysin;neprilysin-390;neprilysin-411;Neutral endopeptidase 24.11;Neutral endopeptidase;Neutral endopeptidase;membrane-associated;SFE;Skin fibroblast elastase

Research Areas:Cancer;Immunology;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P08473

Accession:

Background:This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Concentration:0.4 mg/mL

Immunogen:Synthetic peptide of human MME

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:WB 1:500-1:2000;IHC 1:25-1:100

Calculated MW:86kDa

ObservedMW: