Caspase 4 Rabbit Polyclonal Antibody

SKU: BT-AP06907

Size:100μL

Background:Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.|Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.|PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.|Belongs to the peptidase C14A family.|Contains 1 CARD domain.|subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers| each one formed by a small and a large subunit.|tissue specificity:Widely expressed| with highest levels in spleen and lung. Moderate expression in heart and liver| low expression in skeletal muscle| kidney and testis. Not found in the brain.|

Research_area:Cancer; Cell biology; Metabolism

Target_protein:CASP4

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Caspase 4

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):41470

UniProt accession:Human: P49662; Mouse: P70343

Synonyms:Caspase 4 ;p10; Cleaved-Ala290; Caspase-4; CASP-4; EC 3.4.22.57; ICE;rel-II; Protease ICH-2; Protease TX; Caspase-4 subunit 1; Caspase-4 subunit 2;

GeneID:Human: 837; Mouse: 12363