Canine C-X-C Motif Chemokine 10, CXCL10 ELISA Kit

SKU: E0339Ca

Size:96 Tests-1 Kit

Background:Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).

Research_area:Immunology; Microbiology; Cancer

Applications:ELISA

Target_protein:CXCL10

Reactivity:Canine

Assay type:Sandwich

Sensitivity:13.36ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:C-X-C Motif Chemokine 10

Species:Canine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5KSV9

MASS(Da):10,895

GeneID:478432

Synonyms:C-X-C motif chemokine 10;CXCL10;Small-inducible cytokine B10

Gene names:CXCL10

Standard solution:9600ng/L