Brg-1 rabbit pAb

SKU: ES7238

Size: 100μL

Source:Rabbit

Applications:WB; IF;ELISA

Reactivity:Human;Mouse;Rat

Dilution:WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000

Immunogen:The antiserum was produced against synthesized peptide derived from human Brg-1. AA range:1565-1614

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):200kD

Human_gene_id:6597

Human_swiss_prot_no:P51532

Subcellular_location:Nucleus . Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds. .

Other_name:SMARCA4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S

Background:The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],