Bovine Sialidase-3,NEU3 ELISA KIT

SKU: E0099Bo

Size:96Tests

Background:Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:9988745). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (By similarity). {ECO:0000250|UniProtKB:Q9UQ49, ECO:0000269|PubMed:9988745}.

Research_area:

Applications:ELISA

Target_protein:NEU3

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.19ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sialidase-3

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O97859

MASS(Da):47917

GeneID:281349

Synonyms:NEU3

Gene names:NEU3

Standard solution:48ng/ml