Bovine Beclin 1,BECN1 ELISA KIT

SKU: E0061Bo

Size:96Tests

Background:Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). {ECO:0000250|UniProtKB:O88597, ECO:0000250|UniProtKB:Q14457, ECO:0000250|UniProtKB:Q91XJ1}.; Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000250|UniProtKB:O88597, ECO:0000250|UniProtKB:Q14457}.

Research_area:

Applications:ELISA

Target_protein:BECN1

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.27ng/ml

Detection range:0.5-32ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Beclin1

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q4A1L4

MASS(Da):51581

GeneID:527278

Synonyms:BECN1

Gene names:BECN1

Standard solution:64ng/ml