BICD2 Antibody, FITC conjugated - Cat. #: CSB-PA844723LC01HU

SKU: CSB-PA844723LC01HU

Size :50ug

Clone Number:

Aliases:bA526D8.1 antibody; Bic D 2 antibody; Bic-D 2 antibody; Bicaudal D homolog 2 (Drosophila) antibody; Bicaudal D homolog 2 antibody; Bicd2 antibody; BICD2_HUMAN antibody; Coiled coil protein BICD2 antibody; Cytoskeleton like bicaudal D protein homolog 2 antibody; Homolog of Drosophila bicaudal D antibody; KIAA0699 antibody; Protein bicaudal D homolog 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8TD16

Immunogen:Recombinant Human Protein bicaudal D homolog 2 protein (511-625AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BICD2

Research Areas:Signal transduction