BCL2 (Ab-70) Antibody - Cat. #: CSB-PA129411

SKU: CSB-PA129411

Size :100ul

Clone Number:

Aliases:Apoptosis regulator Bcl 2 antibody; Apoptosis regulator Bcl-2 antibody; Apoptosis regulator Bcl2 antibody; AW986256 antibody; B cell CLL/lymphoma 2 antibody; B cell leukemia/lymphoma 2 antibody; Bcl-2 antibody; Bcl2 antibody; BCL2_HUMAN antibody; C430015F12Rik antibody; D630044D05Rik antibody; D830018M01Rik antibody; Leukemia/lymphoma; B-cell; 2 antibody; Oncogene B-cell leukemia 2 antibody; PPP1R50 antibody; Protein phosphatase 1 regulatory subunit 50 antibody; Protein phosphatase 1; regulatory subunit 50 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P10415

Immunogen:Peptide sequence around aa.68~72 (R-T-S-P-L) derived from Human BCL-2.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

Background:BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Muller IM, et al. (2005) Mol Pharmacol.
Jin Z, Gao F,et al. J Biol Chem 2004 Sep 17; 279(38): 40209-19.
Kumar Biswas S,et al. Mol Cancer Ther 2004 Mar; 3(3): 327-34.
Huang ST,et al. (2002)FASEB J; 16(8): 825-32.
Yamamoto K,et al. (1999) Mol Cell Biol; 19(12): 8469-78.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BCL2

Research Areas:Cancer;Cell biology;Metabolism;Signal transduction