BCAR1 Antibody - Cat. #: CSB-PA134376

SKU: CSB-PA134376

Size :50ul

Clone Number:

Aliases:BCAR 1 antibody; Bcar1 antibody; BCAR1_HUMAN antibody; Breast cancer anti estrogen resistance 1 antibody; Breast cancer anti estrogen resistance 1 protein antibody; Breast cancer anti-estrogen resistance protein 1 antibody; CAS antibody; Cas scaffolding protein family member 1 antibody; CAS1 antibody; Cass1 antibody; Crk associated substrate antibody; Crk associated substrate p130Cas antibody; CRK-associated substrate antibody; CRKAS antibody; FLJ12176 antibody; FLJ45059 antibody; p130cas antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P56945

Immunogen:Synthetic peptide of Human BCAR1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

Background:BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BCAR1

Research Areas:Cancer;Signal transduction