BAP1(Phospho-Ser592) Rabbit Polyclonal Antibody

SKU: BT-AP06274

Size:100μL

Background:This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition| the enzyme may be involved in regulation of transcription| regulation of cell cycle and growth| response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS)| which involves increased risk of cancers including malignant mesothelioma| uveal melanoma and cutaneous melanoma.

Research_area:Cancer; Cell biology; Epigenetics and nuclear signaling

Target_protein:BAP1

applications:WB

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:BAP1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q92560; Mouse: Q99PU7; Rat: D3ZHS6

Synonyms:BAP1 ;Ser592; Ubiquitin carboxyl-terminal hydrolase BAP1; EC 3.4.19.12; BRCA1-associated protein 1; Cerebral protein 6

GeneID:Human: 8314; Mouse: 104416; Rat: 306257