β-Catenin Rabbit pAb

SKU: EA147

Size: 100μL

Source:Rabbit

Applications:WB, IHC

Reactivity:Mouse, Rat

Dilution:WB 1:1,000 IHC 1:500-1,000

Immunogen:Recombinant Protein

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Polyclonal

Isotype:IgG

Concentration:1mg/mL

Observed_band(KD):92kDa

Human_gene_id:1499

Human_swiss_prot_no:P35222

Subcellular_location:Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Synapse

Other_name:beta catenin, b-catenin, CTNB1, CTNNB1, FLJ25606, OTTHUMP00000162082

Background:The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.