ATG7 Rabbit rabbit pAb

SKU: ES20825

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF

Reactivity:Human;Mouse;Rat

Dilution:IHC-p 1:50-300,WB 1:500-2000

Immunogen:Recombinant Protein of ATG7

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):78kD

Human_gene_id:10533

Human_swiss_prot_no:O95352

Subcellular_location:Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .

Other_name:Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7;Autophagy-related protein 7;APG7-like;hAGP7;Ubiquitin-activating enzyme E1-like protein)

Background:This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],