ATG5 Rabbit rabbit pAb

SKU: ES20826

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF

Reactivity:Human;Mouse;Rat

Dilution:IHC-p 1:50-300,WB 1:500-2000

Immunogen:Recombinant Protein of ATG5

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):32kD

Human_gene_id:9494

Human_swiss_prot_no:Q9H1Y0

Subcellular_location:Cytoplasm . Preautophagosomal structure membrane; Peripheral membrane protein. Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .

Other_name:Autophagy protein 5 (APG5-like;Apoptosis-specific protein)

Background:The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015],