ASPM rabbit pAb

SKU: ES10611

Size: 100μL

Source:Rabbit

Applications:IHC;IF

Reactivity:Human;Rat;Mouse;

Dilution:IHC-p 1:50-300

Immunogen:Synthesized peptide derived from human protein . at AA range: 1230-1310

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):382kD

Human_gene_id:259266

Human_swiss_prot_no:Q8IZT6

Subcellular_location:Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule minus ends (By similarity). .

Other_name:

Background:This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011],