APOBEC3C Antibody - Cat. #: CSB-PA889097ESR1HU

SKU: CSB-PA889097ESR1HU

Size :50ul

Clone Number:

Aliases:A3C antibody; ABC3C_HUMAN antibody; APOBEC1 like antibody; APOBEC1-like antibody; APOBEC1L antibody; APOBEC3C antibody; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C antibody; ARDC2 antibody; ARDC4 antibody; ARP5 antibody; bK150C2.3 antibody; DNA dC >dU editing enzyme APOBEC 3C antibody; MGC19485 antibody; PBI antibody; Phorbolin I antibody; Phorbolin I protein antibody; Probable DNA dC dU editing enzyme APOBEC 3C antibody; Probable DNA dC->dU-editing enzyme APOBEC-3C antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NRW3

Immunogen:Recombinant Human DNA dC->dU-editing enzyme APOBEC-3C protein (1-190AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:APOBEC3C

Research Areas:Epigenetics and Nuclear Signaling; Immunology