Anti-XPC Antibody Picoband®

SKU: A00473-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,Flow Cytometry,IF,ICC,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: XPC

Specificity:

Background: Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Immunogen: E.coli-derived human XPC recombinant protein (Position: D146-E838).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Anantharaman, V., Koonin, E. V., Aravind, L. Peptide-N-glycanases and DNA repair proteins, Xp-C/Rad4, are, respectively, active and inactivated enzymes sharing a common transglutaminase fold. Hum. Molec. Genet. 10: 1627-1630, 2001. 2. Balbo Pogliano, C. B., Gatti, M., Ruthemann, P., Garajova, Z., Penengo, L., Naegeli, H. ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair. Nature Commun. 8: 1333, 2017. 3. Ben Rekaya, M., Messaoud, O., Talmoudi, F., Nouira, S., Ouragini, H., Amouri, A., Boussen, H., Boubaker, S., Mokni, M., Mokthar, I., Abdelhak, S., Zghal, M. High frequency of the V548A fs X572 XPC mutation in Tunisia: implication for molecular diagnosis. J. Hum. Genet. 54: 426-429, 2009.

Uniprot ID: Q01831

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 106 kDa

Calculated Molecular Weight: 33477 MW

Gene ID: 7508

Protein Name: DNA repair protein complementing XP-C cells

Gene Full Name: XPC complex subunit, DNA damage recognition and repair factor

Synonyms: XPC complex subunit; DNA damage recognition and repair factor; RAD4; XP3C; p125; XPC