Anti-VGLUT2/SLC17A6 Antibody Picoband®

SKU: A04376-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SLC17A6

Specificity:

Background: Solute carrier family 17 (vesicular glutamate transporter), member 6 is a protein that in humans is encoded by the SLC17A6 gene. The SLC17A6 gene, also known as vesicular glutamate transporter 2 (VGLUT2), encodes a protein responsible for transporting the neurotransmitter glutamate into synaptic vesicles in neurons. This process is crucial for glutamatergic neurotransmission, which plays a fundamental role in synaptic communication and neuronal excitability. SLC17A6/VGLUT2 is primarily expressed in excitatory neurons in various regions of the brain, including the cerebral cortex, hippocampus, and thalamus. Dysregulation of SLC17A6 expression or function has been implicated in neurological disorders such as epilepsy, schizophrenia, and Parkinson's disease, highlighting its significance in brain function and disease pathology. Understanding the molecular mechanisms underlying SLC17A6/VGLUT2 function is essential for unraveling its role in normal synaptic transmission and its potential as a therapeutic target for neurological disorders.

Immunogen: E.coli-derived human VGLUT2/SLC17A6 recombinant protein (Position: M1-K561). Human SLC17A6 shares 98.4% and 98.6% amino acid (aa) sequence identity with mouse and rat SLC17A6, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Aihara, Y., Mashima, H., Onda, H., Hisano, S., Kasuya, H., Hori, T., Yamada, S., Tomura, H., Yamada, Y., Inoue, I., Kojima, I., Takeda, J. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. J. Neurochem. 74: 2622-2625, 2000. 2. Aihara, Y., Onda, H., Teraoka, M., Yokoyama, Y., Seino, Y., Kasuya, H., Hori, T., Tomura, H., Inoue, I., Kojima, I., Takeda, J. Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na(+)-dependent inorganic phosphate cotransporter to human chromosome 11p14.3. Cytogenet. Cell Genet. 92: 167-169, 2001. 3. Bai, L., Xu, H., Collins, J. F., Ghishan, F. K. Molecular and functional analysis of a novel neuronal vesicular glutamate transporter. J. Biol. Chem. 276: 36764-36769, 2001.

Uniprot ID: Q9P2U8

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 64 kDa

Calculated Molecular Weight: 64 kDa

Gene ID: 57084

Protein Name: Vesicular glutamate transporter 2

Gene Full Name: solute carrier family 17 member 6

Synonyms: SLC17A6; DNPI; VGLUT2; Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6