Anti-VEGFR2/KDR Monoclonal Antibody

SKU: MA1040

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: IHC

Application Details: Immunohistochemistry (Frozen Section), 1-2μg/ml, Human

Gene Name: KDR

Specificity: No cross reactivity with other proteins.

Background: VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. The importance of VEGF and its receptor system in tumor growth and intervention in this system may provide promising approaches to cancer therapy. VEGF receptor 2 is a member of a receptor tyrosine kinase family. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues.

Immunogen: Recombinant human extracellular domain of VEGFR-2 (KDR).

Clonality: Monoclonal

Contents: Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3. *This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Ascites

Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Reference: 1. Folkman, J. : Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1: 27-31, 1995. 2. Millauer, B.; Shawver, L. K.; Plate, K. H.; Risau, W.; Ullrich, A. : Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367: 576-579, 1994.

Uniprot ID: O08775

Host: Mouse

Concentration: Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Mouse IgG1

Phospho_site:

Clone Number: Clone: KDR-1

Observed Molecular Weight: 426 kDa

Calculated Molecular Weight: 150394 MW

Gene ID: Human(3791), Mouse(16542), Rat(25589)

Protein Name: Vascular endothelial growth factor receptor 2

Gene Full Name: kinase insert domain receptor

Synonyms: CD309; VEGFR; FLK1; VEGFR2; TYROSINE KINASE GROWTH FACTOR RECEPTOR; FLK1, MOUSE, HOMOLOG OF; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2; Fetal liver kinase 1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1