Anti-v-Myb/MYBL1 Antibody Picoband®

SKU: A05803-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,Flow Cytometry,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: MYBL1

Specificity:

Background: MYB proto-oncogene like 1 is a protein that in humans is encoded by the MYBL1 gene. A-Myb is expressed at specific times in reproductive tissues, some neural cells, and a subset of normal and neoplastic B lymphocytes. Both A-Myb and B-Myb are expressed in t (14:18) lymphoma cells where they then inhibit cell arrest and apoptotic signaling. Expression of B-Myb rescues cells from p53-induced G1 phase arrest that is mediated by p21, while A-Myb functions as an anti-apoptotic factor by effectively activating the bcl-2 promoter and thereby up-regulating Bcl-2 expression.

Immunogen: E.coli-derived human v-Myb/MYBL1 recombinant protein (Position: K199-L752).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Reference: 1. Barletta, C., Druck, T., LaForgia, S., Calabretta, B., Drabkin, H., Patterson, D., Croce, C. M., Huebner, K. Chromosome locations of the MYB related genes, AMYB and BMYB. Cancer Res. 51: 3821-3824, 1991. 2. Nomura, N., Takahashi, M., Matsui, M., Ishii, S., Date, T., Sasamoto, S., Ishizaki, R. Isolation of human cDNA clones of MYB-related genes, A-MYB and B-MYB. Nucleic Acids Res. 16: 11075-11089, 1988. Note: Erratum: Nucleic Acids Res. 17: 1282 only, 1989. 3. Takahashi, T., Nakagoshi, H., Sarai, A., Nomura, N., Yamamoto, T., Ishii, S. Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. FEBS Lett. 358: 89-96, 1995.

Uniprot ID: P10243

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 86 kDa

Calculated Molecular Weight: 16693 MW

Gene ID: 4603

Protein Name: Myb-related protein A

Gene Full Name: MYB proto-oncogene like 1

Synonyms: A-Myb; A-MYB; AMYBMGC120059; MGC120061; Myb-like protein 1; myb-related protein A; MYBL1