Anti-SYNM Antibody Picoband®

SKU: A06653-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SYNM

Specificity:

Background: Synemin, also known as desmuslin, is a protein that in humans is encoded by the SYNM gene. The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene.

Immunogen: E.coli-derived human SYNM recombinant protein (Position: R93-D1554). Human SYNM shares 68.1% amino acid (aa) sequence identity with mouse SYNM.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Gross, M. B. Personal Communication. Baltimore, Md. 2/5/2019. 2. Mizuno, Y., Thompson, T. G., Guyon, J. R., Lidov, H. G. W., Brosius, M., Imamura, M., Ozawa, E., Watkins, S. C., Kunkel, L. M. Desmuslin, an intermediate filament protein that interacts with alpha-dystrobrevin and desmin. Proc. Nat. Acad. Sci. 98: 6156-6161, 2001. 3. Nagase, T., Ishikawa, K., Nakajima, D., Ohira, M., Seki, N., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4: 141-150, 1997.

Uniprot ID: O15061

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 180 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 23336

Protein Name: Synemin

Gene Full Name: synemin

Synonyms: Desmuslin; DMN; KIAA0353; SYN; Synemin; SYNM