Anti-STAT2 Antibody Picoband®

SKU: A01360-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: STAT2

Specificity:

Background: Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA ly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44.

Immunogen: E.coli-derived human STAT2 recombinant protein (Position: D290-D843). Human STAT2 shares 64.8% amino acid (aa) sequence identity with mouse STAT2.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Banninger, G., Reich, N. C. STAT2 nuclear trafficking. J. Biol. Chem. 279: 39199-39206, 2004. 2. Blaszczyk, K., Olejnik, A., Nowicka, H., Ozgyin, L., Chen, Y.-L., Chmielewski, S., Kostyrko, K., Wesoly, J., Balint, B. L., Lee, C.-K., Bluyssen, H. A. R. STAT2/IRF9 s a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1. Biochem. J. 466: 511-524, 2015. 3. Bluyssen, H. A. R., Levy, D. E. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by Stat1 and p48 for stable interaction with DNA. J. Biol. Chem. 272: 4600-4605, 1997.

Uniprot ID: P52630

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 113 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 6773

Protein Name: Signal transducer and activator of transcription 2

Gene Full Name: signal transducer and activator of transcription 2

Synonyms: ISGF 3; P113; STAT113; STAT2