Anti-SLITRK1 Antibody Picoband®

SKU: A07507-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SLITRK1

Specificity:

Background: SLITRK1 (SLIT and NTRK-like family, member 1) is a human gene that codes for a transmembrane and signalling protein that is part of the SLITRK gene family, which is responsible for synapse regulation and presynaptic differentiation in the brain. This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human SLITRK1 recombinant protein (Position: D22-D696). Human SLITRK1 shares 97.5% amino acid (aa) sequence identity with mouse SLITRK1.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Abelson, J. F., Kwan, K. Y., O'Roak, B. J., Baek, D. Y., Stillman, A. A., Morgan, T. M., Mathews, C. A., Pauls, D. L., Rasin, M.-R., Gunel, M., Davis, N. R., Gulhan Ercan-Sencicek, A., and 12 others. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310: 317-320, 2005. 2. Aruga, J., Mikoshiba, K. Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. Molec. Cell. Neurosci. 24: 117-129, 2003. 3. Aruga, J., Yokota, N., Mikoshiba, K. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Gene 315: 87-94, 2003.

Uniprot ID: Q96PX8

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 55 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 114798

Protein Name: SLIT and NTRK-like protein 1

Gene Full Name: SLIT and NTRK like family member 1

Synonyms: TTM; LRRC12; KIAA1910; UNQ233/PRO266; SLIT and NTRK-like protein 1; Leucine-rich repeat-containing protein 12