Anti-SGCE Antibody Picoband®

SKU: A02507-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SGCE

Specificity:

Background: Epsilon-sarcoglycan is a protein that in humans is encoded by the SGCE gene. This gene encodes the epsilon member of the sarcoglycan family. Sarcoglycans are transmembrane proteins that are components of the dystrophin-glycoprotein complex, which link the actin cytoskeleton to the extracellular matrix. Unlike other family members which are predominantly expressed in striated muscle, the epsilon sarcoglycan is more broadly expressed. Mutations in this gene are associated with myoclonus-dystonia syndrome. This gene is imprinted, with preferential expression from the paternal allele. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene associated with this gene is located on chromosome 2.

Immunogen: E.coli-derived human SGCE recombinant protein (Position: Y38-D407).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Asmus, F., Salih, F., Hjermind, L. E., Ostergaard, K., Munz, M., Kuhn, A. A., Dupont, E., Kupsch, A., Gasser, T. Myoclonus-dystonia due to genomic deletions in the epsilon-sarcoglycan gene. Ann. Neurol. 58: 792-797, 2005. 2. Asmus, F., Zimprich, A., Tezenas du Montcel, S., Kabus, C., Deuschl, G., Kupsch, A., Ziemann, U., Castro, M., Kuhn, A. A., Strom, T. M., Vidailhet, M., Bhatia, K. P., Durr, A., Wood, N. W., Brice, A., Gasser, T. Myoclonus-dystonia syndrome: epsilon-sarcoglycan mutations and phenotype. Ann. Neurol. 52: 489-492, 2002. 3. DeBerardinis, R. J., Conforto, D., Russell, K., Kaplan, J., Kollros, P. R., Zackai, E. H., Emanuel, B. S. Myoclonus in a patient with a deletion of the epsilon-sarcoglycan locus on chromosome 7q21. Am. J. Med. Genet. 121A: 31-36, 2003.

Uniprot ID: O43556

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50 kDa

Calculated Molecular Weight:

Gene ID: 8910

Protein Name: Epsilon-sarcoglycan

Gene Full Name: sarcoglycan epsilon

Synonyms: DYT11; Epsilon sarcoglycan; Epsilon SG; ESG; sarcoglycan; epsilon; SGCE; ε-sarcoglycan