Anti-SDE2 Antibody Picoband®

SKU: A15473-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: ELISA,Flow Cytometry,IF,IHC,ICC,WB

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SDE2

Specificity:

Background: Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck.

Immunogen: E.coli-derived human SDE2 recombinant protein (Position: I10-K447).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Jess, F. , Anqi, D. , Abigail, M. , Alexandra, M. M. , Neilj, G. , & Daniel, C. , et al. Sde2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Research(16), 16. 2. Rageul, J. , Park, J. J. , Zeng, P. P. , Lee, E. A. , & Kim, H. . Sde2 integrates into the timeless-tipin complex to protect stalled replication forks. Nature Communications. 3. Julie, R. , Park, J. J. , Ukhyun, J. , Weinheimer, A. S. , Vu, T. T. M. , & Hyungjin, K. . (2019). Conditional degradation of sde2 by the arg/n-end rule pathway regulates stress response at replication forks. Nuclc Acids Research(8), 8.

Uniprot ID: Q6IQ49

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 54 kDa

Calculated Molecular Weight: 24145 MW

Gene ID: 163859

Protein Name: Splicing regulator SDE2

Gene Full Name: spliceosome associated SDE2

Synonyms: SDE2; C1orf55; Replication stress response regulator SDE2; dJ671D7.1; SDE2 telomere maintenance homolog