Anti-SCN1B Antibody Picoband®

SKU: A03061-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Mouse, Rat
ELISA, 0.1-0.5μg/ml, -

Gene Name: SCN1B

Specificity:

Background: Voltage-gated sodium (Na+) channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. The complete coding region of Sodium channel, voltage-gated, beta 1 (SCN1B) is found in approximately 9.0 kb of genomic DNA and consists of five exons (72 to 749 bp) and four introns (90 bp to 5.5 kb). It is mapped to 19q13.1 and can act as a candidate gene for hereditary disorders affecting membrane excitability. Sodium channel beta1 subunits play important roles in the regulation of sodium channel density and localization and are involved in axo-glial communication at nodes of Ranvier.

Immunogen: E.coli-derived human SCN1B recombinant protein (Position: C21-E218).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Makita, N.; Sloan-Brown, K.; Weghuis, D. O.; Ropers, H. H.; George, A. L., Jr. : Genomic organization and chromosomal assignment of the human voltage-gated Na(+) channel beta-1 subunit gene (SCN1B). Genomics 23: 628-634, 1994. 2. Chen, C.; Westenbroek, R. E.; Xu, X.; Edwards, C. A.; Sorenson, D. R.; Chen, Y.; McEwen, D. P.; O'Malley, H. A.; Bharucha, V.; Meadows, L. S.; Knudsen, G. A.; Vilaythong, A.; Noebels, J. L.; Saunders, T. L.; Scheuer, T.; Shrager, P.; Catterall, W. A.; Isom, L. L. : Mice lacking sodium channel beta-1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J. Neurosci. 24: 4030-4042, 2004.

Uniprot ID: Q07699

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 25 kDa, 38 kDa

Calculated Molecular Weight:

Gene ID: 6324

Protein Name: Sodium channel regulatory subunit beta-1

Gene Full Name: sodium voltage-gated channel beta subunit 1

Synonyms: GEFSP1; SCN1B; Sodium channel subunit beta 1