Anti-RGS6 Antibody Picoband®

SKU: A05753-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: RGS6

Specificity:

Background: Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene. This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.

Immunogen: E.coli-derived human RGS6 recombinant protein (Position: D7-E357).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Berman, D. M., Wang, Y., Liu, Z., Dong, Q., Burke, L.-A., Liotta, L. A., Fisher, R., Wu, X. A functional polymorphism in RGS6 modulates the risk of bladder cancer. Cancer Res. 64: 6820-6826, 2004. 2. Chatterjee, T. K., Liu, Z., Fisher, R. A. Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants. J. Biol. Chem. 278: 30261-30271, 2003. 3. Posner, B. A., Gilman, A. G., Harris, B. A. Regulators of G protein signaling 6 and 7: purification of complexes with G-beta-5 and assessment of their effects on G protein-mediated signaling pathways. J. Biol. Chem. 274: 31087-31093, 1999.

Uniprot ID: P49758

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 54 kDa

Calculated Molecular Weight: 16693 MW

Gene ID: 9628

Protein Name: Regulator of G-protein signaling 6

Gene Full Name: regulator of G protein signaling 6

Synonyms: regulator of G protein signaling 6; GAP; HA117; S914; RGS6