Anti-RAG1 Antibody Picoband®

SKU: A00307-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse

Gene Name: RAG1

Specificity:

Background: Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene. The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human RAG1, identical to the related mouse and rat sequences.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Agrawal, A., Eastman, Q. M., Schatz, D. G. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394: 744-751, 1998. 2. Blanquet, V., Turleau, C., Goossens, M., Besmond, C. Assignment of the human recombination activating gene 1 (RAG1) to the 14q21.3-q22.2 region. Genomics 13: 488-489, 1992. 3. Corneo, B., Moshous, D., Gungor, T., Wulffraat, N., Philippet, P., Le Deist, F., Fischer, A., de Villartay, J.-P. Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome. Blood 97: 2772-2776, 2001.

Uniprot ID: P15918

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 119 kDa

Calculated Molecular Weight: 119 kDa

Gene ID: 5896

Protein Name: V

Gene Full Name: recombination activating 1

Synonyms: recombination activating 1; RAG-1; RNF74; RAG1