Anti-ornithine aminotransferase/OAT Antibody Picoband®

SKU: A01126-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.1-0.25μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: OAT

Specificity:

Background: Ornithine aminotransferase (OAT) is an enzyme which is encoded in human by the OAT gene located on chromosome 10. This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.

Immunogen: E.coli-derived human OAT recombinant protein (Position: A214-F439).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Akaki, Y., Hotta, Y., Mashima, Y., Murakami, A., Kennaway, N. G., Weleber, R. G., Inana, G. A deletion in the ornithine aminotransferase gene in gyrate atrophy. J. Biol. Chem. 267: 12950-12954, 1992. 2. Barrett, D. J., Bateman, J. B., Sparkes, R. S., Mohandas, T., Klisak, I., Inana, G. Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp11.2. Invest. Ophthal. Vis. Sci. 28: 1037-1042, 1987. 3. Bisaillon, J. J., Radden, L. A., II, Szabo, E. T., Hughes, S. R., Feliciano, A. M., Nesta, A. V., Petrovic, B., Palanza, K. M., Lancinskas, D., Szmurlo, T. A., Artus, D. C., Kapper, M. A., Mulrooney, J. P., King, T. R. The retarded hair growth (rhg) mutation in mice is an allele of ornithine aminotransferase (Oat). Molec. Genet. Metab. Rep. 1: 378-390, 2014.

Uniprot ID: P04181

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 49 kDa

Calculated Molecular Weight:

Gene ID: 4942

Protein Name: Ornithine aminotransferase, mitochondrial

Gene Full Name: ornithine aminotransferase

Synonyms: HOGA; OAT