Anti-NQO2 Antibody Picoband®

SKU: A03112-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: NQO2

Specificity:

Background: NAD(P)H dehydrogenase, quinone 2, also known as QR2, is a protein that in humans is encoded by the NQO2 gene. This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human NQO2 recombinant protein (Position: M1-Q231).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Gaikwad, N. W., Yang, L., Rogan, E. G., Cavalieri, E. L. Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones. Free Radic. Biol. Med. 46: 253-262, 2009. 2. Jaiswal, A. K., Bell, D. W., Radjendirane, V., Testa, J. R. Localization of human NQO1 gene to chromosome 16q22 and NQO2-6p25 and associated polymorphisms. Pharmacogenetics 9: 413-418, 1999. 3. Jaiswal, A. K., Burnett, P., Adesnik, M., McBride, O. W. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family: extensive polymorphism at the NQO2 gene locus on chromosome 6. (Abstract) Biochemistry 29: 1899-1906, 1990.

Uniprot ID: P16083

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 26 kDa

Calculated Molecular Weight: 64406 MW

Gene ID: 4835

Protein Name: Ribosyldihydronicotinamide dehydrogenase [quinone]

Gene Full Name: N-ribosyldihydronicotinamide:quinone dehydrogenase 2

Synonyms: DHQV; DIA6; NQO2; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; QR2; Quinone reductase 2